Case Study – The use of hypochlorous acid in an OXA-48 multiple drug-resistant Enterobacteriacea-infected lower leg wound (Aug 2021)

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Resistance among pathogenic bacteria to standard antimicrobial agents used for chemotherapy has emerged as a major public health concern globally and is expanding at an alarming rate. The problem is further compounded by the inappropriate and irrational use of antimicrobials, which has driven the emergence of multidrug-resistant (MDR) infection.

Here, we present a case on OXA-48 Klebsiella pneumoniae wound infection, a carbapenemase-producing Enterobacteriaceae MDR Gram-negative bacteria that was treated successfully with hypochlorous acid gauze dressings retained with crepe bandages. This approach was successful in eradicating the OXA-48 infection, and further instrumental in the control of inflammation, which allowed the wound to heal completely within 60 days.

This article was originally published in the South African Journal of Plastic & Reconstructive Aesthetic Surgery & Burns (SAJPRASB), Vol 4 No 1, August 2021.

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